TCA Cycle Mixes

The tricarboxylic acid (TCA) cycle plays an essential role in central carbon and energy metabolism. The study of TCA cycle intermediates (e.g., citrate, α-ketoglutarate, succinate) and its offshoot metabolites (e.g., itaconate and 2-hydroxyglutarate) have proven pivotal in not only understanding their impact on metabolism, but also in profiling their cellular function/fate in oncogenesis, inflammation, and other pathologies (e.g., necrosis, cirrhosis). To aid the analysis of TCA cycle-associated compounds in metabolomic studies, we offer stable isotope-labeled and unlabeled TCA cycle mixes. These mixes are dried down and comprise a collection of TCA cycle and offshoot metabolites.

For the analysis of TCA-associated compounds in metabolic studies, CIL is pleased to offer stable isotope-labeled and unlabeled TCA cycle mixes. These-dried down mixes comprise a collection of TCA cycle compounds as well as offshoot metabolites (see figure below for represented metabolites in red).

Please refer to our TCA Cycle Metabolomics Mixtures flyer (right) for the mix compositions and application examples.